采用猪繁殖与呼吸综合征病毒(PRRSV)变异株HN07-01和经典美洲株BJ-4人工感染2月龄仔猪,通过观察发病情况、检测外周血免疫细胞和PRRSV特异血清抗体水平,研究了不同毒株PRRSV的致病特性.结果表明:PRRSV变异株感染后能够引起高热症状;变异株HN07-01株感染后引起的外周血各类免疫细胞下降速度和下降程度显著高于BJ-4株.提示PRRSV变异株引起机体的免疫抑制明显强于BJ-4株;PRRSV特异血清抗体结果表明:变异株和BJ-4株均能快速诱导机体产生抗体.%In this study, 2-month-old piglets were inoculated with porcine reproductive and respir-atory syndrome virus (PRRSV) variant strain HN07-01 and classical strain BJ-4,respectively. To investigate the pathogenicity of different PRRSV strains, the clinical symptoms was observed and the peripheral blood immune cells and serum PRRSV-specific antibodies were detected. The re-sults showed that the high fever was induced by PRRSV variant strain. Peripheral blood immune cells in HN07-01 infected piglets decreased significantly than that in BJ-4 strain, which indicated the severer immune suppression induced by PRRSV variant. The result of PRRSV-specific anti-body detection showed that both the PRRSV variant and BJ-4 strain can induce antibody quickly.
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