3',3'-二甲基吡喃3',4'2,4,2'-三羟基查尔酮的首次全合成

摘要

3",3"-DimethylpyTano[3',4']2,4,2'-trihydroxychalcone was first synthesized from 2,4-trihydroxyacetophenone and 2,4-dihydroxybenzaldehyde by a four-step reaction of C-prenylation, protection of phenolic hydroxy group, aldol condensation reaction, deprotection in total yield of 18.4%. The structures were characterized by 1H NMR, IR and MS. Intermediate 8 was new compound.%以2,4---羟基苯乙酮和2,4-二羟基苯甲醛为起始原料,经过C-异戊烯基化、保护酚羟基、羟醛缩合、去保护基反应首次成功地完成了天然产物3",3"-二甲基吡喃[3’,4’]2,4,2’-三羟基查尔酮的全合成,总产率18.4％,其结构经1H NMR,IR和MS表征.中间体8未见文献报道.