α-MAP偶氮物的合成

摘要

以α-4-BMA{(3S,4S) -3-[(R)-1-(叔丁基二甲基硅氧基)乙基]4-[(S)-1-甲酰乙基]-2-氮杂环丁酮}为起始原料,通过缩合、水解等反应合成了β-MAP(1β-甲基碳青霉烯双环母核)偶氮物的异构体杂质——α-MAP偶氮物,其结构经1H NMR和IR核磁确证,并建立了相应的分析方法.%A isomer impurity of β-MAP azo compound, α-MAP azo compound, was synthesized from α-4-BMA by condensation, hydrolytic reaction and so on. The structure was confirmed by 1H NMR and IR. In addition, corresponding analytical methods were established.