新型四甲基吡嗪酯类衍生物的合成

摘要

Six tetramethylpyrazine ester derivatives (4a ~ 4f) were synthesized from tetramethylpyrazine by oxidation with hydrogen peroxide and acetic acid to give single nitrogen oxide, in the presence of acetic anhydride rearrangement reaction to form acetylated product, hydrolysis with 20% sodium hydroxide solution to prepare 2-methylol-3,5,6-three methyl pyrazine, lastly catalyzed by EDC1/DMAP. The structures were characterized by 1H NMR, 13C NMR and MS. 4a ~4d were new compounds.%以四甲基吡嗪为原料,在双氧水和醋酸作用下生成四甲基吡嗪的单氮氧化物；单氮氧化物在醋酸酐存在下发生重排反应形成乙酰化产物；乙酰化产物用20％氢氧化钠溶液水解制得2-羟甲基-3,5,6-三甲基吡嗪(2)；2在EDCl/DMAP催化下合成了六个四甲基吡嗪酯类衍生物(4a～4f),其结构经1H NMR,13C NMR和MS表征,其中4a～4d为新化合物.