Knowledge innovation alliance among industries, universities and research institutes forms a complicated knowledge operation system. In the system, knowledge chain is the running mode of knowledge innovation process. In the process of knowledge chain operation , there are some potential risks such as knowledge shared insufficiently, knowledge transferred and fused poorly, transformation and upgrade of knowledge positioning inaccurately, etc. The construction of the risk control mechanism is to build a harmony and soluble, shared mechanism, a rapidly transferred mechanism, and a sustainable operated mechanism. According to the internal logicality of the mechanism, strategic alliance is the best mode of the knowledge innovation alliance, to boost the benefit maximization of knowledge chain operation in the league system. In the strategic alliance, experts of knowledge innovation should play a role not only in the midstream of the knowledge chain, but also throughout the whole process of knowledge chain operation, especially in the downstream ofrnthe knowledge chain-marketing operation.%知识链运行过程潜藏着知识共享不足、知识转移融合不良、知识转型升级定位不准等风险.控制风险机制建设具体表现为和谐共融、共溶的共享机制,快速传递机制,可持续运行机制.而根据机制运行的内在逻辑性,要推动联盟内知识链运行的效益最大化,战略联盟是产学研知识创新联盟最好的模式.在战略联盟内知识创新专家的作用不能停止在知识链的中游,而应贯穿在知识链运行的全过程,直接参与知识链的下游-市场端运作.
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