目的:探讨儿童狼疮性肾炎(LN)的临床、病理及免疫学特点。方法回顾性分析住院治疗的45例LN患儿的临床和病理资料及免疫学指标。结果45例LN患儿中男6例、女39例,平均发病年龄(10.9±2.8)岁。临床表现为急性肾炎综合征型最常见,占42.2%,肾病综合征占31.1%。42例进行病理分型,其中Ⅱ型8例(17.8%),Ⅲ型2例(4.4%),Ⅳ型22例(48.9%),Ⅴ型1例(2.2%),Ⅴ+Ⅲ型3例(6.7%),Ⅴ+Ⅳ型6例(13.3%)。在治疗初期临床缓解率达91.1%,随访24个月15.0%复发。结论 LN患儿的临床表现具有多样性,肾脏病理复杂多变,部分患儿临床表现与肾脏病理表现不一致。%Objective To analyze the clinical and immunological features of 45 pediatric patients with lupus nephritis (LN). Methods Forty-five LN patients were included in this study. Clinical, pathological data and immunological parameters were retrospectively analyzed. Results Forty-five LN patients had 6 males and 39 females, with the mean onset age of (10.9 ± 2.8) years. Acute nephritis was the most common type, accounting for 42.2%. Nephrotic syndrome accounted for 31.1%. Renal biopsy showed class II (17.8%), III (4.4%), IV (48.9%), V (2.2%), V+III (6.7%)and V+IV (13.3%)in 42 cases. The remis-sion rate reached 91.1%in the early therapeutic stage, and 15.0%patients recurred after 24-month follow-up. Conclusions The clinical manifestations of LN children are diverse. The renal pathology is complex. The clinical manifestations in part of the chil-dren are not consistent with renal pathology.
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