β2微球蛋白及血清胱氨酸蛋白酶抑制剂C在高胆红素血症新生儿肾功能评估中的价值

摘要

Objectives To explore the application of serum β2-microglobulin (β2-MG) and cystatin C (CysC) to eva-lu-ate renal function in patients with neonatal jaundice. Metheds Sixty neonates with hyperbilirubinemia from January 2012 to Octorber 2012 in pediatric department were selected and divided into mild group (bilirubin<256.5μmol/L) and moderate severe group (bilirubin≥256.5μmol/L) according to the level of bilirubin. Thirty-four full-term, age- and sex-matched neonates were chosen as healthy controls. Serum β2-MG, CysC, creatinine (Cr) and blood urea nitrogen (BUN) were measured. Results Serum β2-MG and CysC in neonates with hyperbilirubinemia were significantly higher than those in healthy controls (P<0.05), meanwhile, serum Cr and BUN were significantly lower than those in healthy controls (P<0.05). After treatment, serum β2-MG and CysC of neonates with hyperbilirubinemia were significantly decreased, but still higher than those in healthy controls (all P<0.05). Conclusions The neonates with hyperbilirubinemia have the varying degrees of impaired renal function. However, the damage can partially be recovered after treatment.%目的 探讨血清β2 微球蛋白(β2-MG)及血清胱氨酸蛋白酶抑制剂C(CysC)在评估高胆红素血症新生儿肾功能中的价值.方法 收集2012 年1 月至2012 年10 月符合新生儿高胆红素血症诊断标准的新生儿60 例,根据胆红素水平分为轻度组(总胆红素<256.50 μmol/L)及中重度组(总胆红素≥ 256.50 μmol/L),另选年龄、性别相匹配的正常足月新生儿34例作为对照组,测定比较各组新生儿血清β2-MG、CysC 及肌酐(Cr)、尿素氮(BUN)等.结果 两组高胆红素血症新生儿的血清β2-MG及 CysC 高于对照组,血清Cr、BUN 低于对照组,差异均有统计学意义(P 均<0.05).治疗后,高胆红素血症新生儿血清β2-MG及 CysC 低于治疗前,但仍高于对照组,差异均有统计学意义(P 均<0.05).结论 新生儿高胆红素血症对新生儿肾功能有不同程度的损害,经积极治疗后可有所恢复.