先天性肾积水患儿β2微球蛋白、α1微球蛋白水平及临床意义

摘要

Objectives To evaluate the clinical value of serum and urinary levels of β2-MG and α1-MG in evaluation of renal function in children with congenital hydronephrosis. Methods Fourty-eight children with congential hydrohephrosis, among them mild, moderate and sever cases were 10, 12 and 26. Sixteen non-hydronephrosis children were as control group. Radioimmunoassay was used to detect the concentrations of β2-MG and α1-MG in the serum and the urine. The sarcosine oxidase method was used to measure serum creatinine (Scr) level. The clearance of creatinine (Ccr) was calculated. The data was statistically analyzed. Results Compared with the control group, the levels of β2-MG, and α1-MG were significantly increased in children with hydronephrosis and positively correlated with the severity of hydronephrosis. After surgery, β2-MG, and α1-MG levels were significantly declined in children with severe hydronephrosis (P<0.05). There was no significant difference in blood Scr and Ccr between children with different degrees of hydronephrosis and controls (P>0.05). Conclusions β2-MG and α1-MG play a key role in renal function evaluation and clinical follow-up.%目的 探讨血清及尿液β2 微球蛋白(β2-MG)、α1 微球蛋白(α1-MG)水平对评价先天性肾积水患儿肾功能的临床意义.方法选择48 例先天性肾积水患儿,轻、中、重度分别为10、12、26 例;另16 例非肾积水儿童作为对照.采用放射免疫法测定血清及尿液中的β2-MG、α1-MG 水平;肌氨酸氧化酶法检测血清Scr 水平;计算血清内生肌酐清除率(Ccr)水平,并进行统计分析.结果 与非肾积水儿童相比,先天性肾积水患儿血清和尿液β2-MG、α1-MG 水平增高,差异均有统计学意义(P <0.05),且与肾积水的严重程度呈正相关.重度肾积水患儿术后血清和尿液β2-MG、α1-MG 水平均下降,但仍高于非肾积水儿童,差异仍有统计学意义(P<0.05).不同程度肾积水患儿与对照组比较血清Scr 及Ccr 的差异无统计学意义(P>0.05).结论β2-MG、α1-MG 水平对于肾功能监测及随访均有重要的临床意义.