脑钠肽在儿童心血管疾病诊治中的研究进展

摘要

脑钠肽（BNP）是一种主要来源于心室的心脏内分泌激素，具有很强的利钠、利尿、扩张血管、抑制肾素–血管紧张素–醛固酮系统（RAAS）和交感神经系统活性作用。研究表明，心血管疾病患儿的血浆BNP及氨基末端脑钠肽原（NT-proBNP）水平升高，可以反映心室功能变化。该文就BNP/NT-proBNP的生物学特性、检测方法、正常值范围及其在儿童心血管疾病诊治中的研究进展作一综述。%Brain natriuretic peptide(BNP) is a cardiac hormone mainly secreted by myocytes in the ventricular wall. It has strong action of natriuresis, diuresis, vasodilation, inhibition of renin-angiotensin-aldosterone system and sympathetic nervous system. The increased levels of BNP and NT-proBNP have been reported in children’s cardiovascular diseases in numerous stu-dies and can reflect cardiac function. This article simply reviews the BNP and NT-proBNP about its biology character, detection method, medical reference range and its progress in pediatric cardiovascular disease.