1-对氯苯基-3-苯基-5-吡唑啉酮的合成工艺研究

摘要

In the presence of anhydro us ethanol, Ethyl benzoylacetate and 4-Chlorophenylhydrazine hy-drochloride was used as raw materials to synthesize title compounds. The optimum conditions were obtained by single factor orthogonal design method experiment: anhydrous ethano l50ml, dropping time 1 hour, reflux time 3 hours and reflux temperature 80oC. The best yiled of 1-(4-chlorophenyl)-3-phenyl-1H-pyrazol-5 (4H)-one is 99.0%and the purity is higher than 99%.%在无水乙醇的存在下，以苯甲酰乙酸乙酯和对氯苯肼盐酸盐为原料合成标题化合物。采用单因素实验法，得到目标化合物的最佳合成条件：无水乙醇用量50ml，滴加时间1小时，回流时间3小时，回流温度80℃。在最佳合成条件下目标化合物的产物的产率可达99%，产品纯度大于99%。