sRNA调控生物膜形成与细菌耐药性的相关性研究进展

摘要

细菌非编码RNA(sRNA)是一类新发现的、处于细菌基因组非编码区域的基因表达调控因子.sRNA在转录后水平调控靶基因表达,从而影响细胞的个体发育、翻译激活与抑制、细菌毒性等生理功能.近年诸多实验研究证明,sRNA可调控细菌生物膜的形成,对耐药性的产生有一定影响,文章对sRNA调控细菌生物膜形成及其对细菌耐药性产生的影响作一综述.%Small non-coding RNA(sRNA) is a gene expression regulatory factor that is discovered nearly. It is in non-encoding region of bacterial genome,which regulates the expression of target genes in the post-transcriptional level.It affects the physiological functions of cells,such as individual development,the activation of translation,inhibition of translation,bacterial toxicity and so on.In recent years,lots of studies confirm that sRNA has relations with the drug resistance of bacteria and the formation of bacterial biofilm.This review will give a brief overview about sRNA for the formation of bacterial biofilm and its effects on bacteria.