色谱法在花生四烯酸代谢产物检测中的应用

摘要

花生四烯酸（ AA）代谢产物是AA经脂质过氧化产生的一系列物质，参与多种生理及病理生理过程，也是多种疾病的生物标志物，准确的定性、定量分析在研究相关疾病的发生、发展机制，诊断和预测中具有重要价值。在目前已经发现的近70种AA代谢产物中，均为小分子化合物，部分化合物分子结构相似，常规检测技术无法分辨。随着色谱、质谱技术的发展，为AA代谢产物的测定提供了较为可靠的技术手段。文章简要综述了相关进展。%Arachidonic acid ( AA) metabolite is a series of material produced by lipid peroxidation of ( AA) , and it is involved in many physiological and pathological processes.AA metabolites may be potential biomarkers for some diseases.Determining their quality and quantity accurately is significant in the occurrence, development, diagnosis and prediction of some diseases.Nearly 70 kinds of AA metabolites have been found, and they are all small molecule compounds.Conventional determination technology can′t distinguish AA metabolites as their similar molecular structure. The development of chromatography and mass spectrometry provides a reliable technical method for the determination of AA metabolites.This paper gives a general review of the related advances.