抗氨甲酰化蛋白抗体的研究进展

摘要

The key to the treatment of rheumatoid arthritis( RA) is early diagnosis and treatment.It becomes urgent to find sensitive and specific biomarkers for the early diagnosis of RA.In recent years, anti-carbamylated protein ( Carp) antibody is attention.Anti-Carp antibody can improve the susceptibility of anti-citrullinated protein antibody ( ACPA)-negative RA patients, and the anti-Carp antibody presents in about 30% ACPA-negative RA patients.Like ACPA, anti-Carp antibody is also a biomarker for the early diagnosis of RA.This paper will give a review of the progress.%类风湿性关节炎（ RA）诊治的关键是早期诊断、早期治疗，因而找寻敏感而又特异的生物学标志物成为RA早期实验诊断的迫切需要。近年来，抗氨甲酰化蛋白（ CarP）抗体受到关注。抗Carp抗体可提高抗瓜氨酸蛋白抗体（ ACPA）阴性RA患者的敏感性，约30％ACPA阴性RA患者能检测到该抗体。与ACPA一样，抗CarP抗体有望成为RA早期诊断的指标之一。文章就相关研究进展作一综述。