NEUT-X、NEUT-Y参数在细菌感染诊断中的价值探讨

摘要

目的：探讨Sysmex XT-2000i全自动血液分析仪中性粒细胞NEUT-X和NEUT-Y参数对细菌感染诊断的临床意义。方法用Sysmex XT-2000i全自动血液分析仪检测114例细菌感染患者、96例细菌培养阴性组与142名健康体检者（正常对照组）血液样本，分析比较各组中性粒细胞参数NEUT-X、NEUT-Y、C反应蛋白（CRP）和毒性指数（TI）等结果。结果感染组中性粒细胞NEUT-X、NEUT-Y参数分别为1391．4±42．3、450．9±40．9，细菌培养阴性组分别为1344．5±37．0、422．7±45．9，正常对照组分别为1351．7±33．7、415．8±32．2，各组间差异均有统计学意义（P＜0．01）。NEUT-X、NEUT-Y参数与CRP和TI均具有较好的相关性。用于细菌感染诊断时，CRP诊断效能最高，其次为NEUT-X。当CRP、NEUT-X的临界值（Cut-off值）分别取20．5 mg/L、1370．5时，敏感性分别为94．7％、71．1％，特异性分别为71．4％、75．6％。结论感染性疾病患者NEUT-X和NEUT-Y参数明显升高，可作为感染性疾病诊断辅助指标之一。%Objective To investigate the clinical significance of Sysmex XT-2000i automatic hematology analyzer′s neutrophil parameter NEUT-X and NEUT-Y in the diagnosis of bacterial infection.Methods Blood samples were collected from 1 14 patients with bacterial infection,96 patients with bacterial culture negative and 142 healthy subjects (healthy control group)to detect and analyze NEUT-X,NEUT-Y,C-reactive protein (CRP)and toxity indices (TI). Results NEUT-X and NEUT-Y were 1 391.4 ±42.3 and 450.9 ±40.9 respectively in bacterial infection group,which were significantly higher than in bacterial culture negative group (1 344.5 ±37.0 and 422.7 ±45.9)and healthy control group(1 351.7 ±33.7 and 415.8 ±32.2)with statistical significance(P<0.01).NEUT-X and NEUT-Y were correlated with CRP and TI.For the diagnosis of bacterial infection,CRP had the best diagnosis efficacy,and NEUT-X had the secondary diagnosis efficacy.When the cut-off value of CRP and NEUT-X were 20.5 and 1 370.5,the sensitivities were 94.7% and 71.4%,and the specificities were 71.4% and 75.6%,respectively.Conclusions NEUT-X and NEUT-Y parameters increase significantly after bacterial infection.It can be used as assistant diagnosis parameters of bacterial infection.