血清胰岛素样生长因子-1检测在非小细胞肺癌早期诊断中的应用价值

摘要

Objective To study the sigificance of insulin-like growth factor 1 (IGF-1) in the diagnosis of nonsmall cell lung cancer.Methods The serum IGF-1 levels in 90 patients with non-small cell lung cancer and 20 healthy controls were determined by immunoradiometric quantitation assay.Results The levels of serum IGF-1 were significantly higher in non-small cell lung cancer group than in healthy control group [(122.6 ± 20.3) ng/mL and (82.7 ± 20.5) ng/mL,P ＜ 0.05].The levels of IGF-1 in all patients with lymphatic metastasis [(133.2 ± 21.3)ng/mL] were higher than those in patients without lymphatic metastasis [(108.2 ± 15.1) ng/mL,P ＜ 0.05].The levels of IGF-1 in patients at Phase Ⅲ-Ⅳ [(129.3 ± 20.1)ng/mL] were higher than those at Phase Ⅰ-Ⅱ[(115.2 ± 15.2)ng/mL,P ＜ 0.05].In non-small cell lung cancer group,the levels of IGF-1 had a significantly positive correlation with carcinoembryonic antigen(CEA) and cytokeratin-19-fragment (CYERA21-1) respectively(r =0.58 and r =0.49,P ＜0.01).Conclusions High level of serum IGF-1 may have a significant correlation with the pathogenesis,development and metastasis of non-small cell lung cancer,and IGF-1 may have an application significance for the early diagnosis of lung cancer.%目的 探讨胰岛素样生长因子-1(IGF-1)对非小细胞肺癌的诊断意义.方法 应用免疫放射法定量检测90例经病理证实的非小细胞肺癌患者及20名健康对照组血清IGF-1水平.结果 非小细胞肺癌组血清IGF-1水平[(122.6±20.3) ng/mL]明显高于健康对照组[(82.7 ±20.5)ng/mL] (P ＜0.05)；有腋窝淋巴结转移患者的IGF-1水平[(133.2 ±21.3) ng/mL]明显高于未转移患者[(108.2±15.1) ng/mL] (P ＜0.05)；临床TNM分期Ⅲ～Ⅳ期肺癌患者血清IGF-1水平[(129.3 ±20.1) ng/mL]明显高于Ⅰ～Ⅱ期患者[(115.2±15.2)ng/mL](P＜0.05)；肺癌组IGF-1与癌胚抗原(CEA)、细胞角蛋白19片段(CYERA21-1)浓度呈正相关(r=0.58,r=0.49,P均＜0.01).结论 IGF-1在非小细胞肺癌患者外周血中高表达与肺癌的发生、发展及转移有关,在肺癌的早期诊断中具有应用价值.