Transcriptional regulation of E-cadherin and oncoprotein E7 by valproic acid in HPV positive cell lines

摘要

Objective(s):Valproic acid (VPA) has proven to be as one of the most promising useful drug with anticancer properties. In this study, we investigate the VPA effects on E-cadherin expression in HeLa, TC1, MKN45, and HCT116 cell lines. This study assesses the effects of VPA on human papillomavirus E7 expression in HPV positive cell lines.