Protective effect of pentoxifylline on male Wistar rat testicular germ cell apoptosis induced by 34-methylenedioxymeth amphetamine

摘要

Objective(s):3, 4-methylenedioxymethamphetamine (MDMA) one of the methamphetamine derivatives that affect the reproductive system, has not been well understood. Many young people are consumers of drugs such as MDMA that can affect their reproductive capability. Apoptosis is the main mechanism for male infertility. Pentoxifylline (PTX) increases cAMP intracellularly and reduces tumor necrosis factor-α.This study aimed to investigate the protective effect of PTX administration in MDMA-induced apoptosis in testes of male Wistar rats.