THE NEGISHI CROSS-COUPLING REACTION

摘要

Since its inception in 1977the Negishi cross-coupling reaction has had a profound impact on organic synthesis.1 The reaction unites two organic fragments, an organic (pseudo)halide and an organozinc reagent to make a new C-C bond with the elimination of a zinc salt (Scheme 1). The utility of the reaction in linking unsaturated fragments through transition-metal catalysts liken it to its predecessor, the Kumada-Tamao-Corriu reaction that uses more reactive Grignard reagents.2'3 The main advantage of the Negishi reaction is in its wide functional-group compatibility owing to the use of the less nucleophilic organozinc reagents.