KINETIC RESOLUTION AND DESYMMETRIZATION OF ALCOHOLS AND AMINES BY NONENZYMATIC, ENANTIOSELECTIVE ACYLATION

摘要

Enantiomerically pure alcohols and amines are ubiquitous throughout Nature and are found within numerous biologically active compounds. Alcohol and amine functional groups are also synthetically versatile and can be incorporated within a diverse array of synthetic strategies. Consequently, significant efforts have been made toward the development of new methods that permit the preparation of enantiomerically pure alcohols and amines. In this regard, resolution methods in which the two enantiomers of a racemic mixture are separated are still widely used to obtain enantiomerically enriched alcohols and amines.