THE BARTON-McCOMBIE REACTION

摘要

Deoxygenations of alcohols, i.e. processes that replace a hydroxyl group with hydrogen at a saturated carbon, find applications in both total synthesis and the systematic modification of natural products. They may also be employed to introduce deuterium or tritium in a site-specific manner. Reductive methods that involve ionic or highly polarized reagents or intermediates can be limited in their applicability: for example, competing reaction pathways including cationic rearrangements and anionic eliminations may be encountered in sterically hindered systems and with substrates bearing heteroatoms close to the center undergoing reduction.