Protective Role of PI3-kinase/Akt/eNOS Signaling in Mechanical Stress Through Inhibition of p38 Mitogen-Activated Protein Kinase in Mouse Lung

摘要

Acute lung injury (ALI) is a complex syndrome marked by increased vascular permeability resulting in tissue edema and profound hypoxial (1,2). Mechanical ventilation (MV) is often a necessary treatment for respiratory failure and a supportive measure in critically ill patients. However, it is well known that ventilation with high tidal volume (HVT MV) or pressure may be harmful, causing damage to previously healthy lungs or worsening already injured ones. This is especially the case for permeability whereby exacting mechanical stress on various components of the respiratory system can lead to ventilation associated lung injury (VALI). We performed the study described herein in an effort to elucidate the underlying mechanisms of VALI and investigate potential therapies against VALI.