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METHOD OF COMBINED MEDICINAL TREATMENT OF PATIENTS WITH ESSENTIAL UNRESECTABLE REGIONAL SQUAMOUS IB2-IIIB CERVICAL CANCER
METHOD OF COMBINED MEDICINAL TREATMENT OF PATIENTS WITH ESSENTIAL UNRESECTABLE REGIONAL SQUAMOUS IB2-IIIB CERVICAL CANCER
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机译:合并无法治疗的区域性鳞状IB2-IIIB型宫颈癌患者的药物联合治疗方法
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摘要
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely, oncology, and can be used to treat cervical cancer (CC). In the preoperative period, two courses of regional chemotherapy are carried out with an interval of 3 weeks according to the following scheme: a) on the first day before and after the intra-arterial administration of cisplatin, hyperhydration is performed according to the scheme: 2.0 L 0.9 % NaCl supplemented with 20 mM KCl, solution of sodium chloride 400 ml of 0.9 % or 5 % dextrose, furosemide 40 mg (2.0), antiemetics, then intra-arterially administered cisplatin at a dose of 75 mg/mon 400 ml of physiological solution, the administration of cisplatin is performed alternately in the right and left uterine arteries by 200.0 ml of the prepared solution at a rate of 3–4 ml/min; b) the next day, premedication is performed according to the following scheme: 12 and 6 hours before the administration of paclitaxel, 20 mg of dexamethasone is administered intramuscularly, 30–60 minutes before the administration of paclitaxel, 50 mg of diphenhydramine, 300 mg of cimetidine or 50 mg of ranitidine are intravenously administered intravenously, paclitaxel is then given intravenously at a dose of 175 mg/min the form of a 3-hour infusion, diluted to a concentration of 0.3–1.2 mg/ml with a solution of 0.9 % sodium chloride or 5 % dextrose solution. Invention makes it possible to create the maximum concentration of the cytostatic directly in the tumor tissue and simultaneously realize the systemic effect of chemotherapy, as a result of which resorption of the tumor takes place and the process is translated into a resectable state.EFFECT: effect of reducing the volume of the tumor, reducing the pain syndrome and the absence of previously available blood discharges from the genital tract is achieved.1 cl, 4 dwg, 1 ex
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机译:技术领域本发明涉及医学,即肿瘤学,并且可以用于治疗子宫颈癌(CC)。在术前,按照以下方案,每三个星期间隔进行两个疗程的局部化疗:a)在顺铂的动脉内给药前后的第一天,按照该方案进行水合作用: 2.0 L 0.9%NaCl补充20 mM KCl,氯化钠溶液400 ml的0.9%或5%葡萄糖,速尿40 mg(2.0),止吐药,然后以75 mg / mon的剂量经动脉内施用顺铂400 ml在生理溶液中,顺铂的给药是在左右子宫动脉中交替使用200.0 ml制备的溶液以3-4 ml / min的速率进行; b)第二天,按照以下方案进行预防用药:紫杉醇给药前12和6小时,肌肉注射地塞米松20 mg,紫杉醇给药前30-60分钟,苯海拉明50 mg,300 mg静脉内注射50 mg西咪替丁或雷尼替丁50 mg,然后以175 mg / min的剂量静脉输注紫杉醇,每次3小时,以0.9的溶液稀释至0.3–1.2 mg / ml的浓度%氯化钠或5%葡萄糖溶液。本发明使得可以在肿瘤组织中直接产生最大浓度的细胞抑制剂并同时实现化学疗法的全身作用,其结果是发生肿瘤的吸收,并且该过程转化为可切除的状态。减少肿瘤体积,减轻疼痛综合征以及不存在生殖道先前可用的血液排出。1cl,4 dwg,1 ex
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