A method of obtaining functionalized imaging agents with anti-Stokes photoluminescence based on polyacrolein dispersions

摘要

1. The method of obtaining functionalized imaging agents with anti-Stokes photoluminescence in the form of an aqueous dispersion of polyacrolein particles containing nanoscale anti-Stokes phosphors (NAFs) by polymerization of acrolein in an aqueous alkaline medium, carried out in two stages, in the first of which precipitation polymerization is carried out, and in the second stages, the resulting product is subjected to further radical polymerization in the presence of a water-soluble KSO initiator, characterized in that the first polymerization stage is carried out in presence of IFA in an amount of 0.1-1.5% by weight. based on the monomer pretreated with tetramethylammonium hydroxide and use this reagent as a polymerization initiator, the size of the polyacrolein particles containing NAF decreases with a decrease in the concentration of the initial monomer or with an increase in the concentration of tetramethylammonium hydroxide. 2. The method according to claim 1, characterized in that the surface of the polyacrolein particles containing NAF is modified by adding a high molecular weight amino-containing component to the resulting dispersion and stirring at 20 ° C for 2 hours to form functional amino and / or carboxyl on the surface groups.