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METHOD OF INVESTIGATING GENETIC PREDISPOSITION TO DEVELOP JAK2 V617F-POSITIVE MYELOPROLIFERATIVE NEOPLASMS BASED ON THE STUDY OF JAK2 RS10974944 SNP
METHOD OF INVESTIGATING GENETIC PREDISPOSITION TO DEVELOP JAK2 V617F-POSITIVE MYELOPROLIFERATIVE NEOPLASMS BASED ON THE STUDY OF JAK2 RS10974944 SNP
The invention relates to a method of investigating myeloproliferative neoplasms based on the study of JAK2 rs10974944 SNP by genetic analysis. The method claimed by the invention involves genomic DNA extraction, primer selection and PCR-amplification of a genome fragment of the gene JAK2 containing the SNP rs10974944, followed by enzymatic digestion of amplicons with the Mbol restriction enzyme, electrophoresis in agarose gel and accurate genotype identification by analyzing restriction fragments polymorphism.
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