甘草酸二铵肠溶胶囊治疗类风湿关节炎合并肝功能异常临床分析

摘要

Objective To observe therapeutic effect of diammonium glycyrrhizinate enteric-coated capsules for abnormal liver function in patients with rheumatoid arthritis (RA). Methods Total of 90 patients with RA associated elevated aminotransferase were selected, the serious condition of the 45 cases as the treatment group, 45 cases of less severe for the control group, the treatment group taken diammonium glycyrrhizinate enteric-coated capsules. The control group only taken herbs decoction, treatment for 14 days, the changes of clinical symptoms, transaminase, CRP, ESR were observed before and after treatment. Results Clinical symptoms and transaminase changes in the two groups before and after treatment were significantly improved, however, the degree of improvement of the treatment group was signiifcantly better than that of the control group, statistically signiifcant difference (P<0.05). conclusions Diammonium glycyrrhizinate enteric-coated capsules play a signiifcant hepatoprotective role, no adverse effects on rheumatoid situation.%目的：探讨甘草酸二铵肠溶胶囊治疗类风湿关节炎（RA）合并肝功能异常的临床观察。方法选择90例RA患者合并肝功能异常的临床病例，随机分为治疗组和对照组各45例。治疗组给予甘草酸二铵肠溶胶囊150 mg/次，每日3次，治疗2周。对照组给予能量合剂治疗，评价治疗的效果及类风湿活动情况。结果90例RA患者肝功能均有改善，但治疗组较对照组改善更明显，差异有统计学意义（P=0.026），且药物对RA疾病活动度无影响。结论肝功能异常的RA患者可给予甘草酸二铵肠溶胶囊可有效改善肝功能，无不良反应，对类风湿关节炎疾病活动度无影响。