Objective:To investigate deoxynucleotide therapy combined 15-AA degree burns III clinical efficacy and safety. Meth-ods:The study enrolled four hospital 47 cases of deep burns patients in both groups were given admission within 72h corresponding tangen-tial excision, skin graft, anti-infective and nutritional support. Treatment group of 24 patients given deoxynucleotide topical irrigation combined intravenous and combined with 15-AA. A control group of 23 patients given 15, the method of administration fully consistent with aFGF administration methods. Two continuous treatment for 6 weeks, and wound healing, flap survival, serum protein levels in pa-tients with pre-mix and adverse events. Results:The complete healing time, 30d healing rate of skin graft survival area was 44. 2 ± 4. 2d, 75. 0%, 94. 7 ± 5. 8%;the control group were 48. 8 ± 4. 6,43. 5%, 87. 4 ± 6. 4%. Another treatment group 1 patients (4. 2%)occurred sepsis, the control group had five (21. 7%), with a statistically significant difference between the two groups (P <0. 05), treatment group, serum total protein, serum albumin level was 61. 4 ± 6. 3g / L, 31. 4 ± 8. 8g / L. The control group was 55. 2 ± 7. 3 g / L, 27. 4 ± 5. 2 g / L, the two groups had significant difference (P <0. 05). Treatment groups were not significant adverse reac-tions occur. Conclusion:deoxynucleotides can promote wound healing and improve skin flap survival role in raising serum protein levels, could improve the prognosis of patients with severe burns.%目的：：探讨脱氧核苷酸联合15-AA治疗III度烧伤的临床疗效与安全性。方法：入选4个研究医院47例深重度烧伤患者,2组入院72小时内均给予相应的削痂手术、皮片移植、抗感染及营养支持治疗。治疗组24例给予脱氧核苷酸外用冲洗,联合静脉滴注同时联合15-AA。对照组23例给予15-AA,给药方法同aFGF给药方法完全一致。2组连续治疗6周,观察创面愈合情况、皮瓣成活,血清蛋白水平、患者愈合及不良反应发生情况。结果：治疗组完全愈合时间、30天愈合率、皮片成活面积分别为44.2±4.2天、75.0%、94.7±5.8%；对照组分别为48.8 ± 4.6天、43.5%、87.4±6.4%。另外治疗组1例(4.2%)发生脓毒血症,对照组发生5例(21.7%),2组比较具有统计学差异(P<0.05),治疗组血清总蛋白、血清白蛋白水平为61.4±6.3g/L,31.4±8.8g/L。对照组则分别为55.2±7.3 g/L,27.4±5.2 g/L,2组比较具有统计学差异(P<0.05)。治疗过程2组均未发生明显的不良反应。结论：脱氧核苷酸可促进创面愈合,提高皮瓣成活作用,提高血清蛋白水平,改善重度烧伤患者预后。
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