CATALYTIC, ENANTIOSELECTIVE FLUORINATION REACTIONS

摘要

The challenge of developing methods for incorporating fluorine in organic molecules has attracted considerable attention in the synthetic organic chemistry community. The significant interest in this challenge has largely been driven by the unique properties exhibited by organofluorine compounds in comparison to their non-fluorinated analogues.1,2 For example, organofluorine compounds possess increased metabolic stability and enhanced lipophilicity. In addition, the presence of fluorine can modulate pKa values and induce conformational changes governed by the gauche effect.1 As a result, organofluorine compounds have found widespread use in pharmaceuticals, agrochemicals, and advanced materials. It is estimated that 20% of pharmaceuticals and 35% of agrochemicals currently on the market contain fluorine atoms.