COPPER-CATALYZED, ENANTIOSELECTIVE HYDROFUNCTIONALIZATION OF ALKENES

摘要

Alkenes are ubiquitous in nature and are widely available as synthetic building blocks. They constitute an indispensable platform for derivatization,1 and numerous methods have been developed to convert carbon-carbon double bonds into various functional groups in an enantioselective manner.2 Recently, chiral-phosphine-ligated copper(I) hydride (CuH) complexes have emerged as exceptionally effective catalysts for mediating the enantioselective hydrofunctionalization of alkenes. Although the discovery of copper(I) hydride dates back to the 1840s,3 its use in phosphine-ligated form was only identified and applied to organic synthesis in the late 20th century.4-6 Important advances were subsequently made to enable its use in catalytic processes, including the discovery of appropriate stoichiometric hydride sources7-9 and chiral ligands,10 ultimately leading to the development of several enantioselective, copper-catalyzed hydrofunctionalization processes.