1456269 Pyridyl methyl ureas and intermediates therefor ROHM & HASS CO 13 Feb 1974 [19 March 1973] 6594/74 Heading C2C Novel pyridyl-methyl ureas of the Formula I wherein A is a radical -Z-X, wherein Z is a 1,4-phenylene or a 1,4-naphthylene radical and X is a nitro, cyano, trifluoromethyl, -CO-C 1-4 alkyl, mercapto, C 1-6 alkylthio or -SO 2 Y radical, Y being phenyl or -NR 3 R 4 group where R 3 and R 4 are hydrogen atoms or methyl or ethyl groups, are obtained by (1) reacting (3- pyridylmethyl)amine with aryl isocyanates of the formula A-N=C=O, (2) reacting (3-pyridylmethyl)isocyanate with arylamines of the formula A-NH 2 , or (3) reacting C 1-12 alkyl or optionally substituted phenyl - N - (3 - pyridylmethyl)-carbamates or 3-pyridyl methyl urea with arylamines of the formula A-NH 2 . A pesticidal, e.g. rodenticidal composition contains a pyridylmethyl urea of the above formula as active ingredient. 4 - Mercaptophenyl isocyanate and 4 - (tbutylmercapto) phenyl isocyanate are obtained by reacting t-butyl mercaptan with p-chloronitrobenzene to give 4-(t-butylmercapto) nitrobenzene, reducing this to give 4-(t-butylmercapto) aniline and reacting this with phosgene. Phenyl - N - (3 - pyridylmethyl) carbamate is obtained by reacting 3-aminomethyl pyridine with phenyl chloroformate.
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机译:1456269吡啶基甲基脲及其中间体ROHM&HASS CO 1974年2月13日[1973年3月19日]标题C2C其中A为基团-ZX,其中Z为1,4-亚苯基的式I新型吡啶基甲基脲或1,4-亚萘基,且X为硝基,氰基,三氟甲基,-CO-C 1-4烷基,巯基,C 1-6烷硫基或-SO 2 Y基,Y为苯基或-NR 3 R 4通过(1)使(3-吡啶基甲基)胺与式AN = C = O的芳基异氰酸酯反应,(2)使(3-吡啶基甲基)反应,获得其中R 3和R 4为氢原子或甲基或乙基的基团。异氰酸酯与式A-NH 2的芳基胺,或(3)使C 1-12烷基或任选取代的苯基-N-(3-吡啶基甲基)-氨基甲酸酯或3-吡啶基甲基脲与式A-NH 2的芳基胺反应。杀虫剂,例如杀鼠组合物含有上式的吡啶基甲基脲作为活性成分。通过使叔丁基硫醇与对氯硝基苯反应,得到4-(叔丁基巯基)硝基苯,还原它得到4-(叔丁基巯基)苯胺,并使之反应,得到4-巯基苯基异氰酸酯和4-(叔丁基巯基)苯基异氰酸酯。与光气。通过使3-氨基甲基吡啶与氯甲酸苯酯反应获得苯基-N-(3-吡啶基甲基)氨基甲酸酯。
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