Chiral Bronsted Acid-Catalyzed Asymmetric Allylic Alkylation with Indole derivatives

摘要

Nucleophilic allylic substitution reaction is one of the most versatile reactions in organic synthesis. Particularly, asymmetric allylic alkylation reaction is an efficient method for the synthesis of optically active allylic compounds. Whereas the field has been dominated by transition metal catalysis involving chiral π-allyl-metal intermediate, organocatalytic asymmetric transformations utilizing SN2' process have still rarely been explored. Especially, the intermolecular version represents a formidable challenge.